Lipoic Acid for Progressive Multiple Sclerosis (MS)

Exclusion Criteria

• •A self-reported medical or neurological problem other than MS that is a cause of progressive or fluctuating gait dysfunction
• •Unable to undergo MRI
• •Unable to follow directions in English as standardized scales are not all validated in other languages.
• •Current major disease or disorder other than MS (e.g., cancer, renal disease, end-stage cardiopulmonary disease, post-traumatic stress disorder, etc.) that may interfere with study procedures. Note: Stable abnormal laboratory values of no more than Grade 1 determined to not be of clinical significance to the primary treating physician for that condition may be permitted per local site investigator discretion.
• •Pregnant or breast-feeding.
• •Insulin-dependent diabetes or diabetes not controlled on oral diabetes medications.
• •Scheduled (every 3 months or more frequently) IV or oral steroids in the year prior to enrolment.
• •IV or oral steroids in the 60 days prior to enrolment.
• •Use of LA in the prior 2 years exceeding the equivalent of 1200mg daily for 3 months.
• •Participation in the pilot LA in SPMS trial.