Role of Endothelial Biomarkers in Patients With Coronary Artery Disease

1. We are aiming to establish a marker for chronic reactivation and pathophysiology of CMV infection in patients with coronary artery disease. 2. We will be able to answer whether there is a link between the seropositive CMV, telomere length, and CAD. 3. We will correlate the seropositive CMV with telomere length, GDF-15 \& NRF2. 4. We will detect the origin of our biomarkers by human umbilical vein endothelial cells(HUVECS). 5. We will measure the effect of DPP4-I (on TL \& GDF-15 on cardiac cell line). 6. We are looking to establish a new potential risk marker from our study, (GDF-15 \& NRF2) which could be tested in a larger cohort of patients. This would then enable us to identify CMV-seropositive patients at risk and develop novel strategies for future treatment and prevention.