Pharmacologically Triggered Migraine Without Aura and Neuroimaging

Exclusion Criteria

• •Inconsistent laterality of headache
• •History or family history of migraine (healthy subject group only)
• •Tension-type headache more than one day per month on average (healthy subject group only)
• •Tension-type headache to such a degree that the episodic migraine diagnosis is no longer fulfilled
• •Any other primary headache disorder
• •Daily intake of medication (apart from oral contraceptives)
• •Intake of any medication less than 4 half-lives before study start
• •Daily smoking
• •Pregnant or breastfeeding women
• •Headache 48 h prior to study day
• •Hypertension on the study day (systolic BP\>150 mmHg or diastolic BP\> 100 mmHg)
• •Hypotension on the study day (systolic BP\<90 mmHg or diastolic BP\<50 mmHg)
• •History of any cardiovascular disease including cerebrovascular disease
• •Any disorder, that is deemed ineligible for participation by the study physicians
• •Contraindications of MRI
• •No use of safe contraception (women of fertile age only)