Female subjects who are pregnant, intend to become pregnant, or are breastfeeding

History or presence of psychiatric or neurologic disease or condition

History of first-degree relative with schizophrenia or mood disorder with psychosis

History of alcohol or drug abuse

History of recreational ketamine use, recreational PCP use, or an adverse reaction to ketamine

History of violence

Presence or positive history of significant medical illness, including high blood pressure, low blood pressure or orthostatic hypotension

Any subjects who show subthreshold ketamine BOLD response

Metal implants, pacemaker, other metal or paramagnetic objects contained within the body

Claustrophobia

Subject with any history of suicidal behavior or is currently at risk of suicide in the opinion of the investigator

Effects of TS-134 on Ketamine-induced BOLD Signals in Healthy Subjects