HDL Acute Lipid Optimization in Homozygous Familial Hypercholesterolemia

Inclusion Criteria

• •Clinical diagnosis of Homozygous Familial Hypercholesterolemia (HoFH) due to a defect in the LDL receptor, or the identification of a defect in apoB-100, or a gain of function of PCSK9, or a genetic defect resulting in the HoFH clinical phenotype
• •No other condition that would preclude the subject from successfully completing the series of plasmapheresis visits in the investigator's opinion
• •At least one (1) coronary artery study segment will be identified for each subject and all will remain constant throughout the study. The qualifying study segment(s) will have 20% to 40% stenosis.