Patients must have histologically confirmed incurable CRLM and no clinical or radiographic evidence of extrahepatic disease
Patients is medically eligible to receive HAI, as determined by the MDT (multidisciplinary team)
Eastern Cooperative Oncology Group (ECOG) Performance Status 0 or 1
Age \> 18 years
Subject life expectancy \> 3 months
Platelets \> 100×103/mm3
Total bilirubin \<1.5mg/dl
Creatinine level \< 2.0 mg/dl
All patients must sign an informed consent form
You may not be if
The CRLM is amenable to curative surgical therapy
Prior radiation, TACE or HAI to the liver
Uncorrectable coagulopathy
Subject is pregnant, nursing, or wishes to become pregnant during the study Other serious medical condition (uncontrolled infection, uncontrolled cardiac disease) would preclude study treatment or impact survival
Current or planned treatment with any experimental chemotherapy or target drugs
