Saves the questions and what to expect into your notes, next to the visit they belong to.
Keep this study
Lead
University of Nottingham
With
University Hospitals of Derby and Burton NHS Foundation Trust
Nottingham University Hospitals NHS Trust
University Hospital Birmingham NHS Foundation Trust
Age
18–85
Sex
ALL
Healthy volunteers
Not accepted
You may be eligible if
Patients of more than 18 and less than 85 years of age
Patients who have had HVPG measurements within the last 12 weeks.
Underlying portal hypertension due to chronic liver disease - alcoholic liver disease, non-alcoholic fatty liver disease (NAFLD), chronic hepatitis B or C and haemochromatosis.
Patients investigated with a clinical suspicion of portal hypertension, but have normal portal pressures on HVPG measurements.
Ability to consent to participate in the study.
Patients already on NSBBs who have stopped treatment for two weeks
You may not be if
Unable to give informed consent
Patients with underlying diseases which are NOT related to alcohol excess, NAFLD, chronic hepatitis B, C or haemochromatosis.
Pregnant women.
Absolute contraindications for MRI (including participants with metal in/around the eyes)
Absolute contraindications for NSBBs (allergy, presence of asthma)
Patients currently on NSBBs or nitrates (can be included if withheld for two weeks)
mean arterial pressure \<55 mm Hg or pulse \< 50 beats per minute at baseline
