Effects of Probiotic on Modulation of the Intestinal Microbiota in Constipated Patients

Exclusion Criteria

• •Pregnancy or breast-feeding;
• •Known intolerance or allergy to any of the study products;
• •Previous history of gastrointestinal surgery;
• •Patients with celiac disease or inflammatory bowel disease;
• •Patients with psychiatric, cardiologic, respiratory, renal and hepatic disease;
• •No acceptance of study admission by the participant; Diagnosis of Clostridium difficile diarrhea in the last 3 months;
• •Patients with known immunosuppressive disease;
• •Any other gastrointestinal pathology;
• •Prior use of antibiotics in less than 30 days;
• •Frequent use of laxatives or other medication that alters bowel motility (one week without Use before inclusion)
• •Regular treatment with probiotics / symbiotic, including regular use of yogurt with probiotics (One week before use before inclusion)
• •Regular use of antidepressant, opioid analgesic, antispasmodic or anticholinergic agents