Use of Lexiscan for Myocardial Stress Perfusion Computed Tomography With a 3rd Generation Dual Source CT System

Exclusion Criteria

• •1. Subject is a pregnant or nursing female. Exclude the possibility of pregnancy:
• •* By testing (serum or urine beta HCG) within 24 hours before study agent administration, or
• •* By surgical sterilization, or
• •* Post menopausal, with minimum one (1) year history without menses.
• •2. Subject has severe asthma or COPD requiring frequent inhaler use.
• •3. Subject has prior diagnosis of obstructive CAD that has not been revascularized.
• •4. Subject with implanted rhythm devices (pacemaker, defibrillator).
• •5. Subject has significant arrhythmia.
• •6. Subject has high grade heart block.
• •7. Subject has resting heart rate \< 45 bpm, systolic blood pressure \<90 mm Hg, or has consumed caffeine within the last 12 hours.
• •8. Subject has an acute psychiatric disorder.
• •9. Subject is unwilling to comply with the requirements of the protocol.
• •10. Subject has previously entered this study.
• •11. Subject has an allergy against iodinated contrast agents or pharmaceutical stressors used in this study.
• •12. Subject suffers from claustrophobia.
• •13. Subject has impaired renal function (creatinine \> 1.5 mg/dl).
• •14. Subject is in unstable condition.
• •15. ST-elevations, new transient ST changes greater than 0.05mV or T- wave inversions with symptoms
• •16. Subject cannot safely be administered Lexiscan™ per prescribing information as determined by investigator
• •17. Subject has received interventional (PCI, stenting) or surgical (CABG) treatment that may alter the cardiac condition regarding myocardial perfusion status and/or stenosis degree between cardiac CTA, SPECT, and/or CT stress perfusion studies.