An Open-label, Non-comparative Study to Document the Tolerability to Ramipril in Patients With at Least One High Risk for Developing a Major Cardiovascular Event

Inclusion Criteria

• •Man or woman, age 55 years old or more.
• •Presence of a high risk of developing a major cardiovascular event, defined as at least one of the following underlying conditions:
• •Clinical evidence of coronary artery disease (examples: previous myocardial infarction \[MI\], positive stress test or significant stenosis at coronary angiography, previous Percutaneous Trans-Luminal Coronary Angioplasty \[PTCA\], previous Coronary Arterial Bypass Grafting \[CABG\]);
• •Clinical evidence of peripheral vascular disease (examples: history of intermittent claudication with positive Doppler or angiography, previous limb bypass surgery, previous percutaneous trans-luminal angioplasty, previous limb or foot amputation);
• •Previous stroke;
• •Diabetes (insulin-dependent or non-insulin dependent) with at least one of the following cardiovascular risk factors:
• •hypertension (blood pressure \[BP\] \>140/90 mmHg, or patients on antihypertensive treatment);
• •hypercholesterolemia (total cholesterol \> 5.2 mmol/L \[\>200 mg/dL\]);
• •low HDL cholesterol (\< 0.9 mmol/L \[\<3.5 mg/dL\]);
• •current cigarette smoking;
• •documented microalbuminuria (30-300 mg/24 hours);
• •Evidence of previous vascular disease.