Prefatory Study to Explore Changes in Nasal Mucociliary Clearance and to Standardize Nasal Scraping Procedure

Inclusion Criteria

• •Male smokers aged ≥25 to ≤45 years old.
• •Male never smokers aged ≥25 to ≤45 years old.
• •Subject's BMI is comprised between 18.0 kg/m2 to 32.0 kg/m2, inclusive.
• •Subject is healthy, as judged by the Investigator.
• •Non-menthol cigarette smokers:
• •* A positive urine cotinine test (≥200 ng/mL).
• •* Smoked at least 20 cigarettes per day for at least the past 5 years.
• •* eCO levels \>10 parts per million (ppm).
• •* No plans to quit smoking in the next 3 months.
• •Never smokers:
• •* Subject who has smoked less than 100 cigarettes throughout their lifetime and no cigarettes in the past 3 years.
• •* A negative urine cotinine test (\<200 ng/mL).
• •* eCO levels ≤ 5 ppm.