EMPRA (EMPagliflozin and RAs in Kidney Disease)

Inclusion Criteria

• •for CKD patients with type 2 diabetes
• •Estimated GFR (calculated with the MDRD-IDMS formula) between 15 and 59 ml/min (with CKD stage IIIa/b to IV)
• •Albumin excretion rates of 30-300 mg/24 hours (UACR \<300 mg/g)
• •Fasting plasma glucose levels \>126 mg/dl \[7mmol/L\] or HbA1c levels \>6.5% (Definition of type 2 diabetes according to the diagnostic criteria set forth by the American Diabetes Association in 2009)
• •for CKD patients without Diabetes
• •Estimated GFR (calculated with the MDRD-IDMS formula) between 15 and 59 ml/min (with CKD stage IIIa/b to IV)
• •Albumin excretion rates of 30-300 mg/24 hours (UACR \<300 mg/g)