Effects of Fructose Restriction on Liver Steatosis

Exclusion Criteria

• •Medical history of liver disease
• •(History of) excessive alcohol consumption (defined as \> 2 units/day for women, and \> 3 units/day for men)
• •Major change in weight and/or physical activity prior to the study
• •Use of glucose lowering drugs
• •Recent illness
• •Pregnancy and/or lactation
• •Contraindications for magnetic resonance imaging
• •Inability to give informed consent
• •Protocol change (implemented on July 18, 2018): in order to increase the inclusion of study participants, subjects with an average daily fructose intake \< 45 gram/day will also be eligible for participation. In subjects who have an average daily fructose intake \< 45 gram/day, supplementation of either fructose or glucose (see 'Arms and Interventions') will be increased to 45 gram/day.