Hyperventilation Versus Exercise Testing Sensitivity in Exercise Induced Asthma

Inclusion Criteria

• •The subject must have a diagnosis of asthma according to 2010 Canadian Thoracic Society consensus criteria since more then one year.
• •The subject should have an average expiratory volume per second (FEV1) ≥ 80% of the predicted value (post bronchodilatation) at the time of the initial visit.
• •The subject must have had a positive methacholine test at the first visit of the study demonstrating the presence of bronchial hyperreactivity.
• •The subject must have asthma control as defined by 2010 Canadian Thoracic Society consensus, with the obvious exception of limitations related to physical activity.
• •The subject must have at the questionnaire significant symptoms of exercise-induced bronchospasm for more than 6 months.
• •The subject should not have a positive history of eczema, urticaria or allergic rhinitis for life.
• •The subject should have a FEV1 ≥ 80% of the predicted value and an FEV1 / FVC (Forced vital capacity) ratio of ≥70% at the time of the initial visit.
• •The subject should have a negative methacholine test at the first visit of the study.
• •The subject should not exhibit symptoms considered clinically compatible with EIB diagnosis.