E-cigarettes and Cardiovascular Function

Exclusion Criteria

• •Non-ambulant people and people with a recent (e.g. within 6 months) cardiovascular disease event (e.g. stroke, myocardial infarction) or cardiac surgery,
• •people with insulin-controlled diabetes mellitus or with coexisting skin conditions, leg ulcers, vasculitis or deep venous occlusion (as these may affect their cardiovascular function),
• •pregnant women,
• •people who require major surgery (which will prevent them of taking part in the study)
• •people who following referral to the smoking cessation services, are advised that Nicotine Replacement Therapy is not appropriate for them,
• •people who are currently using e-cigarettes on a daily basis, or currently undertaking an attempt within a smoking cessation service,
• •people who are judged to be unable or are unwilling to give informed consent.
• •The study team will assess prospective participants and will not include in the study those who appear too frail or have health problems (e.g. dementia, Alzheimer's etc.) that might prevent them of giving a conscious, informed consent.