Genetic Determinants of ACEI Prodrug Activation

Exclusion Criteria

• •The presence of a known medical condition that would preclude the use of enalapril
• •The presence of any surgical or medical condition (active or chronic) that may interfere with drug absorption, distribution, metabolism, or excretion.
• •A positive urine pregnancy test in the MCRU prior to the study
• •No subjects weighing under 50 kg will be selected
• •The lack of use of acceptable methods of birth control unless abstinent
• •Subjects who regularly take medications, vitamins, herbal supplements
• •The use of any illicit drugs or habitual consumption of large quantities of ethanol (\>3 drinks/day)
• •The consumption of grapefruit or grapefruit juice a week prior to, and during the study
• •Asians will not be included in the study as the CES1 SNP G143E is absent in this population
• •Subjects hypersensitive to enalapril
• •Subject with a history of angioedema
• •Smokers