Saves the questions and what to expect into your notes, next to the visit they belong to.
Keep this study
Lead
Hospices Civils de Lyon
Age
18–65
Sex
ALL
Healthy volunteers
Not accepted
You may be eligible if
Patient of age \>18 years and \<65 years
Victim of direct experience trauma (accident or physical aggression)
Presence of an ASD between D3 and D7 after the trauma according to DSM V criteria
You may not be if
Contra-indication to prazosin: orthostatic hypotension, right heart failure, other hypotensive therapy, 5-phosphodiesterase inhibitors (sildenafil) or diuretic, history of syncope or severe unexplained faintness, hypersensitivity known to quinazolines.
Alcohol and / or drug use at the time of the trauma
History of psychotic disorder
Suicidal risk defined by a score ≥ 2 on the Suicidal Ideas Item of the Beck Depression Inventory (BDI)
Protected or vulnerable Major
Persistence of a life threatening injury at D3
Sexual assault
Only moderate head trauma can be included and therefore excluded patients with loss of consciousness greater than 30 minutes, Glasgow score less than 13, post-traumatic amnesia greater than 24 hours (Ruff et al., 2009) .
Prescription of morphine or morphine derivative in progress
Pregnancy or breastfeeding period
Lack of effective contraception in a woman susceptible to childbearing
Known hepatic dysfunction
Narcolepsy (Gelineau's disease)
Cardiac or vascular history including coronary artery disease
Strict low-sodium diet
Clareo Health | Efficacy of Prazosin in Preventing Post-traumatic Stress Disorder
