Identifying Targets of Maladaptive Metabolic Responses in Heart Failure

Inclusion Criteria

• •1. Subjects are capable of giving informed consent.
• •2. Age 19-89
• •3. Diagnosis of chronic heart failure
• •4. Any patients scheduled for at least one of the following procedures:
• •1. LVAD implantation or as recipient for cardiac transplantation.
• •2. LVAD placement both as bridge to transplant and as destination therapy.
• •3. LVAD explantation
• •4. Valve replacement or repair
• •5. Catheterization and myocardial biopsy for idiopathic cardiomyopathy
• •6. Coronary artery bypass graft (CABG)
• •1. Samples collected from non-failing hearts deemed unsuitable for transplantation by TransLife because of either acute recipient issues or post-harvest evidence of pathology or positive but benign serology.
• •2. Normal cardiac function from medical records