Propranolol for Treating Fibromyalgia Pain

Exclusion Criteria

• •General Health Criteria:
• •* Uncontrolled/unstable illnesses (physician diagnosed, self-report)
• •* Pregnancy or planning to be pregnant in the next year
• •* Having Asthma requiring medication treatment including inhaler
• •* Type I diabetes or Type II diabetes requiring medical therapy that can lead to hypoglycemia
• •* Having acute pain or neuropathic pain
• •* Participation in exercise or psychological treatment studies in the past 2 years
• •* Having known serious psychopathology: Psychosis, history of inpatient psychiatric admission in the past year, active suicidal intent, history of self-injurious behaviors in the past year, history of recreational IV drug use, substance abuse history in the past year)
• •Cardiovascular Criteria:
• •* Having known cardiovascular diseases (self-report, physician diagnosed)
• •* Pacemaker
• •* Bradycardia (resting heartrate of less than 55 bpm)
• •* Resting diastolic BP \< 55 mmHG or systolic BP\<100 mmHG
• •* ECG showing prolonged PR interval \> .2 sec
• •* ECG showing irregular PR interval
• •* ECG showing incongruence between P wave and QRS
• •Medication Criteria
• •* Allergy or intolerance of beta blockers
• •* Current use of the following drugs:
• •* Antihypertensive drugs
• •* Neuroleptics
• •* Monoamine oxidase inhibitors
• •* Tizanidine
• •* Amphetamine-based medications
• •* Bupropion
• •* Mirtazapine
• •* Tricyclics: daily dose greater than 75mg amitriptyline or equivalent
• •* Benzodiazepine: daily dose greater than 5mg diazepam or equivalent
• •* Asthmatic medicine, including inhaler
• •* Participants may be included after minimum of 4 weeks of physician prescribed termination of these drugs