Study of E6007 in Japanese Patients With Moderate Active Ulcerative Colitis

Exclusion Criteria

• •Reduction in partial Mayo score of ≥3 points at Baseline from Screening
• •Diagnosed with right-sided or segmental colitis, and proctitis from a Baseline endoscopy
• •Received any anti-tumor necrosis factor (TNF) agent for over 2 years, or within 12 weeks prior to Baseline
• •History of colectomy, or planning to have surgery for treatment of UC at Screening or Baseline
• •White blood cell count below 3000/microliters (µL) at Screening
• •History or suspected history of central nervous system disorder found at Screening or Baseline
• •Current complication or suspected malignancy or toxic megacolon at Screening or Baseline
• •Prior history or current complication of colonic dysplasia at Screening or Baseline
• •History of any severe drug allergy at Screening or Baseline
• •Received a live vaccine within 4 weeks prior to Baseline
• •QTc repeatedly above 450 milliseconds (ms) on the electrocardiogram (ECG) test at Screening
• •In the case of women: nursing mothers or pregnant women at Screening or Baseline
• •Refusal to use medically suitable contraception (both the participant and the participant's partner) throughout the entire study period, if the participant is a man capable of reproduction or a woman of childbearing potential
• •Female participants who want to become pregnant or male participants whose partners want to become pregnant throughout the entire study period
• •Evidence of clinically significant disease that in the opinion of the investigator(s) could affect the participant's safety or interfere with the study assessments at Screening or Baseline
• •History of any medical conditions or concomitant medical conditions that in the opinion of the investigator(s) would compromise the participant's ability to safely complete the study at Screening or Baseline
• •A positive finding on the human immunodeficiency virus antigen and antibody test at Screening
• •In tests conducted at Screening, a positive finding for any of the following: hepatitis B virus surface antigen, hepatitis B virus surface antibody, hepatitis B virus core antibody, or hepatitis C virus antibody
• •Any result other than negative on the tuberculosis test at Screening
• •Findings indicating a history of tuberculosis on chest X-ray during Screening
• •History of drug or alcohol dependency or abuse within approximately the last 2 years prior to Screening or Baseline
• •Use of illegal recreational drugs at Screening or Baseline
• •Currently enrolled in another clinical trial or used any investigational drug or device within 16 weeks preceding informed consent