Functional Magnetic Resonance Imaging of N-acetylcysteine in Cocaine Dependence

Exclusion Criteria

• •1. Do not meet DSM-IV criteria for cocaine-use disorder.
• •2. Meet DSM-IV psychiatric classifications for lifetime schizophrenia or bipolar disorder, or exhibit significant current suicidal or homicidal plans and intent such that hospitalization is required.
• •3. Meet DSM-IV criteria for current alcohol or other substance-use disorder dependence (with the exceptions of nicotine, cocaine and opioids).
• •4. Have previously taken or currently take NAC.
• •5. Have asthma (due to possible complications with NAC).
• •6. Cannot commit to 4-weeks of study participation or are unwilling to accept randomization.
• •7. Have any contraindications for MRI scanning (e.g., pregnancy, color-blindness, claustrophobia, metal implants that could interfere with MRI, any other contraindication to scanning).
• •8. Have lab work (complete blood count, urinalysis, liver function tests, thyroid function tests) suggesting the presence of any abnormalities or have a significant or unstable medical illness.
• •9. Are women who are pregnant or of a child-bearing age who do not agree to adequate contraception to prevent pregnancy during the study period.
• •10. Are not fluent in English.
• •11. Do not have at least a 6th grade reading level.
• •12. Cannot provide written, informed consent.