Is Detoxification Needed in Medication-overuse Headache?

Exclusion Criteria

• •Severe physical illness or psychiatric disorders.
• •Addiction to alcohol or other drugs.
• •Current treatment with headache prophylaxis. Patients can be included minimum 5 weeks after stop of prophylaxis.
• •Pregnancy, breastfeeding or planned pregnancy within the next 12 months.
• •Inability to provide reliable information about medical history.
• •Criteria for Control group 1 - Episodic migraineurs:
• •Episodic migraine, with/without concomitant tension-type headache, according to the ICHD-III beta.
• •Headache days / month ≤ 6 at time of inclusion.
• •Days with analgesics / month ≤ 6 at time of inclusion.
• •Prophylactics are allowed.
• •Age ≥ 18 years old.
• •Ability to fill out headache calendar.
• •No previous medication overuse.
• •No significant co-morbid pain, physical or psychiatric disorders.
• •No addiction to alcohol or drug-abuse.
• •No pregnancy, breastfeeding or planned pregnancy within the next 12 months.
• •Criteria for Control group 2 - Healthy volunteers:
• •≥ 2 days with headache in the past month at time of inclusion.
• •Days with analgesics / month ≤ 6 at time of inclusion.
• •Age ≥ 18 years old.
• •No significant co-morbid pain, physical or psychiatric disorders.
• •No addiction to alcohol or drug-abuse.
• •No pregnancy, breastfeeding or planned pregnancy within the next 12 months.