Interest of in Situ Terlipressin Administration Before the Realisation of Bronchial Biopsy

Exclusion Criteria

• •Patients with contraindication to the use of terlipressin:
• •septic shock ,
• •Hypersensitivity to terlipressin or the excipients or by whom use the product is not recommended:
• •Recent history (\<3 months) of acute coronary syndrome (including myocardial infarction) or unbalanced coronary insufficiency, or disorders of the ventricular heart rate.
• •severe uncontrolled hypertension,
• •cerebrovascular insufficiency and ischemic stroke of recent origin (\<3 months).
• •severe arterial occlusive lower extremities,
• •severe chronic renal impairment (GFR \<20 ml / min).
• •Patients receiving uninterrupted antiplatelet therapy during 5 days before endoscopy (7 days for Clopidogrel Related), including low dose aspirin (≤ 75 mg / day).
• •Patients receiving anticoagulant therapy:
• •Unfractionated heparin within 12 hours before endoscopy.
• •low molecular weight heparin within 24 hours before endoscopy.
• •Patients with bleeding disorders defined by TP below 70% or TCA ratio patient / control greater than 1.3.
• •Patients with thrombocytopenia less than 100 g / L.
• •Subjects misunderstanding of spoken and written French
• •Person under guardianship or deprived of liberty by judicial or administrative decision (under Article L1121-6 and L1121-8 of Public Health Code
• •Pregnant or lactating women, premenopausal women without adequate contraception
• •Patient participating in other drug testing or participating in another drug test in the previous month