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Keep this study
Lead
University Hospital, Basel, Switzerland
Selective quantification of RAS peptides in human plasma triggered investigations evaluating whether RAS peptides could be used as clinical biomarkers in patients receiving antihypertensive treatment.
Drug-specific RAS profiles first characterized in healthy normotensive subjects (EKBB 255/12; ClinicalTrials.gov ID NCT01771783) are presently investigated in patients with newly diagnosed arterial hypertension (EKNZ 2015-081; clinicaltrials.gov identifier (ID) NCT02449811). With this observational study RAS peptide profiles will be characterized in patients with treatment resistant hypertension. Data generated by this study will show whether RAS peptide profiles merit further evaluation as clinical biomarkers in this complex patient group.
Age
18–any
Sex
ALL
Healthy volunteers
Not accepted
You may be eligible if
Office blood pressure ≥ 140/90 mmHg and mean 24 hour blood pressure \>130/80 mmHg on average, or \>135/85 mmHg during the day, or \> 120/70 mmHg during the night, despite concurrent use of 3 antihypertensive agents at optimal doses, including one diuretic OR
Office blood pressure and 24 hour mean blood pressure controlled with four or more medications
* Age ≥ 18 years
* Ability to understand research procedures and to provide written informed consent
You may not be if
Known secondary arterial hypertension at time of inclusion or diagnosis of secondary hypertension after study inclusion during routine work-up of treatment resistant hypertension
Known obstructive sleep apnea at time of inclusion
History of, or clinically relevant or uncontrolled cardiovascular disease (other than arterial hypertension), namely myocardial infarction within last 3 months or valvular heart disease with clinically relevant reflux or heart failure
Any circumstances or conditions, which, in the opinion of the investigator, may affect full participation in the research project or compliance with the research plan.
Clareo Health | RAS Peptide Profiles in Patients With Treatment-resistant Arterial Hypertension
