Documented egg and/or imiquimod allergy

Previous life-threatening reaction to seasonal influenza vaccine (i.e. Guillain-Barré Syndrome)

Previous severe reaction to imiquimod cream

Pregnancy or breast-feeding

Patients with autoimmune diseases

For HIV-infected patients:

* Current active opportunistic infection

For kidney transplant recipients:

* Ongoing therapy for rejection (including steroid pulse or prednisone \> 2 mg/kg/day over more than 14 days)

* Ongoing therapy with IVIG and eculizumab or current and past (\<6months) therapy with rituximab

Imiquimod and Influenza Vaccine for Immunocompromised Patients