Chronic kidney disease patients with hyperuricemia and glomerular filtration rate (GFR) 20-60 ml/min were treated by febuxostat or benzbromarone. Follow up the changes of serum uric acid, serum creatinine and GFR levels. Compare the effects on renal function of these two drugs.
Age
18–75
Sex
ALL
Healthy volunteers
Not accepted
You may be eligible if
Chronic kidney disease patients with glomerular filtration rate (GFR,20-60ml/min) who match one of the following criteria:
1. Gout
2. serum uric acid \> 480umol/L
You may not be if
1. GFR\<20ml/min or GFR \>60ml/min
2. Liver dysfunction (Aspartate transaminase or/and alanine aminotransferase exceed 2 times of normal range)
3. Urinary tract obstruction
4. unstable angina, heart failure (stage III-IV, NYHA), new stroke, need diuretics for long-term treatment
5. Severe lung diseases or cancers
6. Pregnant woman or woman who prepare to be pregnant，nursing mothers
7. unable to sign informed consent form，or disagree with following-up
