Influence of Metoclopramide on Ticagrelor Pharmacokinetics and Pharmacodynamics in Patients With Unstable Angina Pectoris on Concomitant Treatment With Morphine

Exclusion Criteria

• •treatment with ticlopidine, clopidogrel, prasugrel or ticagrelor within 14 days before the study enrollment
• •current treatment with morphine or any opioid "mi" receptor agonist
• •hypersensitivity to ticagrelor
• •current treatment with oral anticoagulant or chronic therapy with low-molecular-weight heparin
• •active bleeding
• •history of intracranial hemorrhage
• •recent gastrointestinal bleeding (within 30 days)
• •history of coagulation disorders
• •platelet count less than \<100 x10\^3/mcl
• •hemoglobin concentration less than 10.0 g/dl
• •history of moderate or severe hepatic impairment
• •history of major surgery or severe trauma (within 3 months)
• •risk of bradycardic events as judged by the investigator
• •second or third degree atrioventricular block during screening for eligibility
• •history of asthma or severe chronic obstructive pulmonary disease
• •kidney disease requiring dialysis
• •manifest infection or inflammatory state
• •Killip class III or IV during screening for eligibility
• •respiratory failure
• •history of severe chronic heart failure (NYHA class III or IV)
• •concomitant therapy with strong CYP3A inhibitors (ketoconazole, itraconazole, voriconazole, telithromycin, clarithromycin, nefazadone, ritonavir, saquinavir, nelfinavir, indinavir, atazanavir) or strong CYP3A inducers (rifampicin, phenytoin, carbamazepine, dexamethasone, phenobarbital) within 14 days and during study treatment
• •body weight below 50 kg