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Lead
University of Utah
Ten individuals with treatment resistant major depressive disorder will undergo 10 treatments of deep anesthesia via propofol over a 3-week period. Depression will be evaluated before and after treatment.
Age
18–55
Sex
ALL
Healthy volunteers
Not accepted
You may be eligible if
• Diagnosis of Major Depressive Disorder (MDD) or bipolar Disorder (I or II, most recent episode must be depression
* Failed at least 2 anti-depressant treatments and no ECT in past 6 months
* Age between 18-55 years
* BMI \< 35
* Hamilton Rating Scale for Depression (HSRD) score \> 18
* Quick Inventory of Depression Scale (QIDS) score \> 10.
You may not be if
• Diagnosis of primary psychotic disorder, dysthymia, or personality disorder
* Significant pre-morbid cognitive impairment
* Hypertension and current use of ACE inhibitor or AR blocker medications
* Symptomatic coronary artery disease or congestive heart failure
* History of transient ischemic or neurologic signs during the past year
* History of or susceptibility to malignant hyperthermia
* Contraindication to isoflurane or propofol anesthesia (as determined by anesthesiologist)
* Diabetes requiring insulin
* Poor kidney function
* Chronic use of benzodiazepines or opioids
* Individuals incompetent to provide consent (e.g. catatonic, psychotic).
Clareo Health | Burst Suppression Anesthesia for Treatment of Severe Depression
