Intraoperative Electron Beam Radiotherapy Boost in Treating Patients With Stage I-II Breast Cancer Undergoing Surgery With Reconstruction

Exclusion Criteria

• •Clinical T4, N2 or N3, M1 pathologic stages III or IV breast cancer
• •Prior invasive non-breast malignancy (except non-melanoma skin cancer, carcinoma in situ of the cervix) unless disease free for a minimum of 3 yrs prior to study entry
• •Prior invasive or in-situ carcinoma of the breast (prior lobular breast carcinoma in situ \[LCIS\] is eligible)
• •Two or more cancers not resectable through a single lumpectomy incision
• •Bilateral breast cancer
• •Ductal breast carcinoma in situ (DCIS) only
• •Non-epithelial breast malignancies such as sarcoma/lymphoma
• •Male breast cancer
• •Paget's disease of the nipple
• •Prior radiotherapy to the breast or prior radiation to the region of the ipsilateral breast that would result in overlap of radiation fields
• •Pregnancy or women of childbearing potential who are sexually active and not willing/able to use medically acceptable forms of contraception
• •Active systemic lupus, erythematosus, or any history of scleroderma, dermatomyositis with active rash
• •Medical, psychiatric or other condition that would prevent the patient from receiving the protocol therapy or providing informed consent