Age

18–any

Sex

ALL

Healthy volunteers

Not accepted

A diagnosis of primary inherited EM with family history of EM made at least 3 months from initial diagnosis.
Failed at least one prior treatment for EM (defined as an inadequate response or intolerance to treatment).
Approved concomitant medications must have been stable for at least 4 weeks prior to day 1.

Positive screening Hepatitis B surface antigen or positive Hepatitis C antibody result.
Received nerve blocks and/or steroid injections for neuropathic pain within 4 weeks prior to Day 1.
Males whose partner is pregnant.
Failed at least one prior treatment for EM (defined as an inadequate response or intolerance to treatment).

A Phase 2a Study of BIIB074 in the Treatment of Erythromelalgia