Extension of SoluMatrix TM Abiraterone Acetate in Patients Who Completed Study Number CHL-AA-201

Exclusion Criteria

• •1. Progressive disease as ascertained by the investigator using standard-of-care evaluations.
• •2. CHL-AA-201 D84 blood counts of the following:
• •1. Absolute neutrophil count \> 1500/µL
• •2. Platelets \> 100,000/µL
• •3. Hemoglobin \> 9 g/dL
• •3. CHL-AA-201 D84 chemistry values of the following:
• •1. Alanine aminotransferase (ALT) and aspartate aminotransferase (AST) \< 2.5 x Upper Limit of Normal (ULN)
• •2. Total bilirubin \< 1.5 x ULN
• •3. Creatinine\< 1.5 x ULN
• •4. Albumin \> 3.0 g/dL
• •5. Potassium \> 3.5 mmol/L