Trial of Vitamin D Supplementation in Cape Town Primary Schoolchildren

Exclusion Criteria

• •Age ≤5 years or ≥12 years at enrolment
• •Previous positive Interferon-Gamma Release Assay (IGRA) or Mantoux test
• •Previous treatment for LTBI or active TB
• •Clinical signs of rickets
• •History of myalgia on walking
• •Inability to rise unaided from squatting position
• •Taking supplemental vitamin D at a dose \>400 IU daily or equivalent in the previous month
• •Diagnosis of any chronic illness other than asthma
• •Suspected HIV infection in child with parent or legal guardian declining to have child HIV-tested
• •Use of any regular medication other than asthma medication
• •Plans to move away from study area within 3 years of enrolment
• •Unable to swallow one placebo softgel with ease
• •Positive Quantiferon-TB Gold Plus test at screening