Finding studies
Finding studies
Take this into the appointment.
Saves the questions and what to expect into your notes, next to the visit they belong to.
Lead
Louisiana State University Health Sciences Center in New Orleans
Pulmonary hypertension patients who choose to participate: Written informed consent will be obtained for the study. Patients must sign the informed consent before participating in any study related procedures. * All inclusion and exclusion criteria will be reviewed. * Demographic history will be recorded. * Vital signs will be performed. * A medication history will be taken. * A smoking history will be recorded. * BNP levels will be measured as a part of usual care at PH visits. * Ultrasonographic measurements will be performed at the clinic visit. * Ultrasonographic measurements: IVC Measurements * Performed in the subcostal view in supine position. * Images will be captured in a video format. * Maximal IVC diameter 1 to 2 cm from the junction of the right atrium and the IVC at end-expiration just proximal to the junction of the hepatic veins. The IVC collapsibility index to give an estimate of RAP. * Inspiratory collapse of \> 50% or \< 50% will be ascertained based on the measurements. Jugular Vein Measurements * Patient will be placed in 45° position * Longitudinal images will be obtained of the right jugular vein. * Location of tapering of the jugular vein is measured, and distance from the sternal angle is recorded as ultrasound-measured jugular venous pressure (JVP). Clinical Worsening Outcomes • At each visit during year 1, and then every 6 months for years 2-3, clinical worsening events will be captured. These events are defined as: * Death * PH-related hospitalization * Lung transplant * Atrial septostomy * Functional Class worsening and step up in therapy Study Timing * Enrollment of patients for a period of 1 year. Subsequently, no more patients will be enrolled. Patients who are enrolled will be followed clinically without further study-related testing at their regular clinic visits after completion of year 1. * All patients enrolled will have ultrasonographic measurements of IVC and jugular veins at each clinic visit for 1 year. * Data collection regarding meeting clinical worsening end points and BNP levels will be collected at the regular clinic visits at year 2 and 3 of the study. * If patients are lost to follow up at clinics (including year-1), telephone correspondence, social security database review or chart review at 6-month intervals will be performed to determine vital status and see if they have met any clinical worsening endpoints. * Study will close after the final patient has completed 3-years of follow up.
Age
18–any
Sex
ALL
Healthy volunteers
Not accepted
