Lead Sponsor

The University of Texas Health Science Center, Houston

Age

18 - 75 years

Sex

ALL

Healthy Volunteers

No

•Spontaneous subarachnoid hemorrhage
•Presentation to hospital within 72 hours of symptoms
•Fisher grade 3 hemorrhage (thick subarachnoid clot) on initial computed tomography (CT) scan
•Hunt and Hess grade 1-5 at time of randomization
•Presence of a cerebral aneurysm on computed tomographic angiography (CTA) or Angiogram for which clipping or coiling is possible
•Ability to obtain medication within 36 hours of presentation

•subarachnoid hemorrhage (SAH) due to causes other than aneurysm rupture (trauma, arteriovenous malformation (AVM), mycotic aneurysms, Moyamoya)
•Pre-existing disability with modified Rankin Scale (mRS) score ≥2,
•Renal disease as defined by creatinine clearance less than 9 milliliters/min
•History of severe hepatic impairment (Child-Pugh score of 10-15)
•History of chronic obstructive pulmonary disease (COPD) or asthma
•History of dementia
•Co-morbid conditions likely to complicate therapy, including clinically significant arrhythmia, acquired immune deficiency syndrome (AIDS), autoimmune disease, malignancy, and expected mortality within 72 hours
•Expected mortality within 72 hours as determined by PI, treating neurointensivist and neurosurgeon. (Clinically manifested by no attempt at securing aneurysm)
•Females who are pregnant.