Transfusion Dependency at Diagnosis and Transfusion Intensity During Initial Chemotherapy Are Associated With Poorer Outcomes in Adult Acute Myeloid Leukaemia

Exclusion Criteria

• •Patients with M3 AML of French-American-British (FAB) classification (APL, Acute Promyelocytic Leukemia)
• •World Health Organization (WHO) performance status \>2; (ii)
• •Left ventricular systolic ejection fraction below the normal range
• •Patients who have any severe and/or uncontrolled medical conditions or other conditions that could affect their participation in the study
• •Serum creatinine concentration \> 2x ULN (Upper Limit of Normal laboratory ranges),
• •AST or ALT levels \> 2.0 x upper limit of normal (ULN), except if AML-related