Describe the profile of the 4 neurodegeneration's biomarkers of Alzheimer's disease dosed in the cerebrospinal fluid (Total Tau proteins, phosphorylated, Aß40 and Aß1-42) for old subjects suffering from bipolar disorder with or without cognitive impairment.
Age
60–80
Sex
ALL
Healthy volunteers
Not accepted
You may be eligible if
male or female between 60 and 80
french-speaking, reading and writing patient
affiliation to the French Social Security
written informed consent obtained from the patient
agree to undergo a lumbar puncture
easy accessibility for the lumbar puncture
Mini Mental State Examination (MMSE) \> 20
bipolar patients :
* type I or II
* state of euthymia for at least 4 weeks
* stable psychotropic drug treatment for at least 8 weeks
* no electroconvulsive therapy during the 6 months before inclusion
distribution in the "with cognitive disorder" or "without cognitive disorder" group is function of the result of the neuropsychological evaluation
severe visual or auditory disorder
advanced lumbar osteoarthritis
history of severe head injury, neurological disorders, diagnosed dementia
addiction weaned for less than 12 months
forced hospitalization in psychiatry
MRI contraindications
LP contraindications
You may not be if
\- at least one of the outcome measures can't be performed :
