Comparison of His Bundle Pacing and Bi-Ventricular Pacing in Heart Failure With Atrial Fibrillation

Exclusion Criteria

• •Subjects with the width of ECG Q, R, S wave (QRS) complex \>120ms
• •Subjects with life expectancy less than 3 years
• •Subjects with mechanical right heart valve
• •Subjects with primary valvular disease
• •Subjects with heart transplant, or is currently on a heart transplant list
• •Subjects who are pregnant, or of childbearing potential and not on a reliable form of birth control
• •Subjects with significant renal dysfunction, as manifested by serum creatinine level \>2.5 mg/dl or ≥275 μmol/L or estimated glomerular filtration rate (GFR) ≤30 mL/min/1.72 m2, which is documented within the 30 days prior to enrollment or at baseline.
• •Subjects with significant hepatic dysfunction, as evidenced by a hepatic function panel (serum) \> 3 times upper limit of normal, which is documented within the 30 days prior to enrollment or at baseline.
• •Subjects with chronic or treatment-resistant severe anemia (hemoglobin \<10.0 g/dL), which is documented within the 30 days prior to enrollment or at baseline