Food Reward in Cachexia Induced by Acute or Chronic Disease

Exclusion Criteria

• •Contra-indications for fMRI examination (operation to your head or brain in the past; implanted electronic devices, for instance a pacemaker, neurostimulator, cochlear or hearing implant; insulin pump under your skin; Pregnant subjects, claustrophobia; pregnancy; metal parts in your body (except from teeth filling and connectors): implants; brain vessel clamps, prostheses, intra-uterine device, metal splinter in the eye, metal braces or other metal objects, permanent eye make-up)
• •Psychiatric or other disorders likely to impact on informed consent
• •Presence of brain metastasis (screening is not mandatory)
• •Medical history of cerebrovascular accident, brain tumour, brain metastasis
• •Previous radiotherapy to brain, both stereotactic and whole brain radiotherapy
• •Memory problems
• •Current use of tube feeding or parental nutrition
• •Patients with an active second malignancy
• •Patients unable to lie still for 2 hours
• •Unable to complete the cognitive task
• •Pre-existing swallowing difficulties
• •Allergy to gluten-, milk- or wheat products
• •Self-reported hyperthyroidism
• •Self-reported diabetes mellitus
• •Current use of appetite stimulant medications