Injectable Collagen Scaffold™ Combined With HUC-MSCs Transplantation for Patients With Decompensated Cirrhosis

Inclusion Criteria

• •Participants must meet all of the following criteria:
• •1. Subjects who are decompensated cirrhosis of any cause.
• •2. Subjects are repeated exacerbations despite treatment and hospitalized more than once within one year because of complications of cirrhosis, (e.g., massive ascites, spontaneous bacterial peritonitis, gastrointestinal bleeding or hepatic encephalopathy).
• •3. Need intermittent plasma albumin and oral diuretics supplement.
• •4. Serum albumin \<35 g/L, total bilirubin\<170 μmol/L, prothrombin activity \>30% (prothrombin time \<20 s), moderate or mild ascites, spontaneous bacterial peritonitis and hepatic encephalopathy have been cured, Child-pugh score ≥7.
• •5. Peripheral blood hemoglobin concentration\> 70g/L，platelet count \> 3 × 10\^9/L, hematocrit (HCT) level\>0.25.
• •6. No gastrointestinal bleeding during the last one month before enrolment.
• •7. Patient has no conditional to undergo orthotopic liver transplantation (OLT).
• •8. Willing to sign informed consent.