Investigating Central Mechanisms of Overactive Bladder in Adults With Parkinson's Disease

Exclusion Criteria

• •Women who are breast-feeding, pregnant or have the potential to become pregnant during the course of the study (fertile and unwilling/unable to use effective contraceptive measures).
• •Cognitive deficits that in the opinion of the investigator would interfere with the subject's ability to give informed consent or perform study testing.
• •Evidence of Urinary Tract Infection (UTI) at screening.
• •Bladder pain or history of chronic inflammation such as interstitial cystitis, recurrent UTIs, bladder stones, bladder obstruction, previous pelvic radiation therapy, or previous or current malignant disease of the pelvic organs.
• •Adults who have an interstim device in place.
• •Claustrophobia, occupational risk for ferrous metal in the eye, or having an implantable medical device or foreign body precluding fMRI (e.g. cardiac pacemaker, metallic fragment, orthopedic hardware).
• •Intravesical botulinum toxin treatment within the previous six months of screening.
• •Use of indwelling catheter or self-catheterization.
• •Any other serious and/or unstable medical condition