Lead Sponsor

Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center

Age

18 - 65 years

Sex

ALL

Healthy Volunteers

No

•Patients between 18-65 years of age evaluated in the emergency department at Harbor-UCLA with migraine headache as defined by the Headache Classification Committee of the International Headache Society. (Patients must have had at least one prior similar headache, with or without nausea, vomiting, aura, photophobia, or phonophobia).
•Only subjects able to consent to treatment will be included.

•Patients with the following conditions:
•pregnancy
•breastfeeding
•fever greater or equal to 100.4 degrees
•diastolic blood pressure of 105 or higher
•altered mental status
•meningeal signs
•suspicion for intracranial process requiring further investigation
•known allergy to prochlorperazine
•the use of ergotamines, antiemetics, antipsychotics or sedatives in the previous 24 hours of study entry.