There is preliminary evidence suggesting that MultiParametric Magnetic Resonance Imaging (MP-MRI) can be a marker for prostate cancer (PCa) aggressiveness and could be used to plan treatment. Gleason grade (GG) is a critical predictor of the aggressiveness of PCa, but in up to one in three men, the histology of radical prostatectomy specimens is different from the histology of Transrectal Ultrasound (TRUS)-guided biopsies. This discrepancy contributes to- and is a sign of- poor risk stratification of men with localised PCa.
The research aims to answer the following questions:
1. Can image-fusion techniques allow investigators to reliably target abnormal areas seen on MP-MRI?
2. How reliable is pre-biopsy MP-MRI in correctly predicting aggressive disease?
The investigators envisage that MP-MRI information will reduce unnecessary biopsies and over-detection of indolent PCa, while improving the detection of aggressive disease.
Primary Objectives
• To determine whether using MP-MRI can improve cancer detection and characterization of prostate cancer
Secondary Objectives
• To determine whether US/MRI FUSION guided biopsy can reduce the number of false negative biopsies.
