A Study to Evaluate Efficacy and Safety of a Fixed Combination Ocular Insert in Participants With Open-angle Glaucoma or Ocular Hypertension

Exclusion Criteria

• •Any known contraindication to prostaglandin analog (latanoprost, travoprost, bimatoprost, tafluprost) or timolol
• •A cardiac or pulmonary condition that in the opinion of the Investigator would contraindicate the use of a topical beta-blocker
• •Use of any agents known to have a substantial effect on IOP during planned study period (e.g. beta-blockers)
• •Cup-to-disc ratio of greater than 0.8
• •Significant risk of angle closure due to pupil dilation, defined as a Shaffer classification of less than Grade 2 based on gonioscopy
• •Ocular, orbital, and/or eyelid surgery of any type within the past six (6) months from screening date
• •Laser surgery for glaucoma / ocular hypertension on one (1) or both eyes within the last six (6) months
• •Past history of any incisional surgery for glaucoma at any time
• •Past history of corneal refractive surgery
• •Corneal abnormalities that would interfere with accurate IOP readings with an applanation tonometer
• •Current participation in an investigational drug or device study or participation in such a study within 7 days of Screening
• •Inability to adequately evaluate the retina
• •Subjects who will require contact lens use during the study period.
• •Subjects who currently have punctal occlusion
• •Pregnant, lactating or of child-bearing potential and not using a medically acceptable form of birth control