A Clinical Research of NK Cell Infusion Combined With Chemotherapy in the Treatment of Non-small Cell Lung Cancer

Inclusion Criteria

• •1. Non-small cell lung cancer must be diagnosed by pathology and staged as ⅢB or Ⅳ with 2009-UICC TNM staging system and operation is excluded due to medical reasons or patient's will.
• •2. According to Response Evaluation Criteria in Solid Tumors(RECIST), at least one measurable or evaluable nidus can be detected by chest CT.
• •3. ECOG score 0-1.
• •4. Gender is not limited, age from 18 years to 75 years.
• •5. Patients are expected to survive for more than 3 months by their physicians at the time of enrollment.
• •6. Mental state is evaluated as normal.
• •7. Adequate cardiac function(LVEF≥40%, tested within one month) without heart diseases.
• •8. Hepatic and renal function were normal, biochemical criterion must meet the requests below: white blood cell count≥2.5×10\^9/L，platelet count≥100×10\^9/L，hemoglobin≥90g/L, serum bilirubin≤2 upper limit of normal(ULN), AST and ALT≤2 ULN(AST, ALT≤5ULN under hepatic metastases), Bun≤2 ULN, serum creatinine≤2 ULN.
• •9. No other serious illnesses(e.g.,autoimmune disease, immunodeficiency, ect.).
• •10. Ability to give informed consent.
• •11. No other malignancies diagnosed.
• •12. Patients volunteer to participate in the research.