Lead Sponsor

Institute of Liver and Biliary Sciences, India

Age

12 - 75 years

Sex

ALL

Healthy Volunteers

No

•Patients with acute liver failure defined as : Patients with jaundice which is complicated by encephalopathy and coagulopathy within 4 weeks of the onset of jaundice and without underlying chronic liver disease.

•Age \<12 or \> 75 years
•Hepato-Cellular Carcinoma
•Active untreated Sepsis/DIC
•Any evidence of active bleed secondary to coagulopathy
•Hemodynamic instability requiring high dose of Vasopressors
•Coma of non-hepatic origin.
•Pregnancy
•Comorbidities associated with poor outcome (Extrahepatic neoplasia, severe cardiopulmonary disease defined by a New York Heart Association score \>3, or oxygen/steroid-dependent chronic obstructive pulmonary disease).
•Patients being taken up for liver transplant
•Refusal to participate in the study.

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