Patients who was confirmed non-small cell lung cancer (NSCLC) by histology or cytology, harboring EGFR mutant type (19 and/or 21 exon mutation).
Patients who was confirmed with asymptomatic, treatment naive brain metastasis (didn't receive any treatment after diagnosed with brain metastasis) by MRI, couldn't receive operation or stereotactic radiosurgery（SRS）.
Appraisable disease, that is there must be at least one lesion with the longest diameter\>10mm in brain (by brain MRI).
Adult patients (18 to 75 years old). Eastern Cooperative Oncology Group（ECOG） performance status 0 to 2. Life expectancy of at least 12 weeks. Haemoglobin \> 10g/dl, absolute neutrophil count (ANC) \> 1.5 x 10\^9/L, platelets \> 100 x 10\^9/L; total bilirubin \< 1.5x upper limit of normal (ULN). Alanine aminotransferase（ALT） and aspartate aminotransferase（AST）\< 1.5x ULN in the absence of liver metastases, or \< 5x ULN in case of liver metastases. Creatinine clearance \> 60ml/min (calculated according to Cockcroft-gault formula).
Patients should be contraceptive during the period of the trial.
You may not be if
Patients who had received brain radiotherapy or EGFR-TKI before.
Patients who can't receive WBRT.
Uncontrolled intracranial hypertension after steroid or dehydration therapy.
Patients who take phenytoin, Carbamazepine, Rifampicin, Barbital, or St John's Wort which will interfere with the metabolism of TKI.
Patients with interstitial lung disease, significant ocular disease, or serious uncontrolled systematic disease.
Patients who can't take oral tablets, with active peptic ulcer diseases.
Pregnancy or breast-feeding women.
Clareo Health | EGFR-TKI Concurrent With/Without WBRT in Brain Metastasis From NSCLC
