Saves the questions and what to expect into your notes, next to the visit they belong to.
Keep this study
Lead
University Hospital, Bordeaux
Age
40–any
Sex
ALL
Healthy volunteers
Accepted
You may be eligible if
1. No history or evidence of retinal pathology or glaucoma
2. Normal Humphrey 24-2 Visual Field (VF) : A mean defect (MD), corrected pattern standard deviation (CPSD) within 95% limits of normal reference, and glaucoma hemifield test (GHT) within normal limits (97%).
3. Intraocular pressure \< 21 mm Hg
4. Open angle (Shaffer's grading system)
5. Normal appearing Optic Nerve Hypoplasia (ONH) and Nerve Fiber Layer (NFL) : intact neuroretinal rim without peripapillary hemorrhages, notches, localized pallor, or NFL defect
6. Symmetric ONH between left and right eyes: Cup-to-Disc Ratio (CDR) difference \< 0.2 in both vertical and horizontal dimensions
1. ONH or NFL defect visible on slit-lamp biomicroscopy defined as one of following:
* diffuse or localized thinning of the rim
* disc (splinter) hemorrhage
* notch in the rim
* vertical cup/disc ratio greater than the fellow eye by \> 0.2
2. Consistent glaucomatous pattern on both qualifying Humphrey Swedish Interactive Threshold Algorithm (SITA) 24-2 VF meeting at least one of the following quantitative criteria for abnormality:
* PSD outside normal limits (p \< 0.05)
* GHT outside normal limits (p \< 0.01)
PPG participants must have at least one eye meeting all of the following criteria:
1. ONH or NFL defect visible on slit-lamp biomicroscopy defined as one of following:
* diffuse or localized thinning of the rim
* disc (splinter) hemorrhage
* notch in the rim
* well-defined peripapillary NFL bundle defect.
* inter-eye vertical CDR asymmetry \> 0.2
2. Baseline VF not meeting the criteria for the PG group.
3. Risk factors for glaucoma, one of following:
* Intraocular pressure \> 21 mm Hg
* Ethnics
* Family history of glaucoma
You may not be if
1. Age \< 40
2. Refractive error of \> +6.00 D or \< -6.00 D (SE), +3,00 D for astigmatism
3. Diabetic retinopathy
4. Other diseases that may cause VF loss or optic disc abnormalities
5. Inability to clinically view or photograph the optic discs due to media opacity or poorly dilating pupil
6. Inability to perform reliably on automated VF testing
7. Insufficient quality of Spectralis OCT images (this is not determined until after Spectralis OCT examination, and is an unusual circumstance). Minimum requirements are:
* Retina completely included in image frame,
* Quality Score ≥ 15 in the stored mean images,
8. Refusal of informed consent
Clareo Health | SD-OCT Multimodal Analysis in GLaucoma
