SD-OCT Multimodal Analysis in GLaucoma

Inclusion Criteria

• •1. No history or evidence of retinal pathology or glaucoma
• •2. Normal Humphrey 24-2 Visual Field (VF) : A mean defect (MD), corrected pattern standard deviation (CPSD) within 95% limits of normal reference, and glaucoma hemifield test (GHT) within normal limits (97%).
• •3. Intraocular pressure \< 21 mm Hg
• •4. Open angle (Shaffer's grading system)
• •5. Normal appearing Optic Nerve Hypoplasia (ONH) and Nerve Fiber Layer (NFL) : intact neuroretinal rim without peripapillary hemorrhages, notches, localized pallor, or NFL defect
• •6. Symmetric ONH between left and right eyes: Cup-to-Disc Ratio (CDR) difference \< 0.2 in both vertical and horizontal dimensions
• •1. ONH or NFL defect visible on slit-lamp biomicroscopy defined as one of following:
• •* diffuse or localized thinning of the rim
• •* disc (splinter) hemorrhage
• •* notch in the rim
• •* vertical cup/disc ratio greater than the fellow eye by \> 0.2
• •2. Consistent glaucomatous pattern on both qualifying Humphrey Swedish Interactive Threshold Algorithm (SITA) 24-2 VF meeting at least one of the following quantitative criteria for abnormality:
• •* PSD outside normal limits (p \< 0.05)
• •* GHT outside normal limits (p \< 0.01)
• •PPG participants must have at least one eye meeting all of the following criteria:
• •1. ONH or NFL defect visible on slit-lamp biomicroscopy defined as one of following:
• •* diffuse or localized thinning of the rim
• •* disc (splinter) hemorrhage
• •* notch in the rim
• •* well-defined peripapillary NFL bundle defect.
• •* inter-eye vertical CDR asymmetry \> 0.2
• •2. Baseline VF not meeting the criteria for the PG group.
• •3. Risk factors for glaucoma, one of following:
• •* Intraocular pressure \> 21 mm Hg
• •* Ethnics
• •* Family history of glaucoma