Short Bowel Syndrome Research Study for Children Up To 17 Years of Age on Parenteral Nutrition

Exclusion Criteria

• •1. Subjects who are not expected to be able to advance oral or tube feeding regimens
• •2. Serial transverse enteroplasty or any other bowel lengthening procedure performed within 3 months of screening
• •3. Known clinically significant untreated intestinal obstruction contributing to feeding intolerance and inability to reduce parenteral support
• •4. Unstable absorption due to cystic fibrosis or known DNA abnormalities
• •5. Severe, known dysmotility syndrome, such as pseudo-obstruction or persistent, severe, active gastroschisis-related dysmotility, that is the primary contributing factor to feeding intolerance and inability to reduce parenteral support, prior to screening. Dysmotility is defined as severe if it is expected to limit the advancement of enteral feeding.
• •6. Evidence of clinically significant obstruction on upper GI series done within 6 months prior to screening.
• •7. Major GI surgical intervention including significant intestinal resection within 3 months prior to the screening visit (insertion of feeding tube, anastomotic ulcer repair, minor intestinal resections ≤ 10 cm, or endoscopic procedure is allowed).
• •8. Unstable cardiac disease, congenital heart disease or cyanotic disease, with the exception of subjects who had undergone ventricular or atrial septal defect repair, and patent ductus arteriosus (PDA) ligation.
• •9. History of cancer or clinically significant lymphoproliferative disease, not including resected cutaneous basal or squamous cell carcinoma, or in situ non aggressive and surgically resected cancer.
• •10. Pregnant or lactating female subjects (in the teduglutide treatment arm only).
• •11. Participation in a clinical study using an experimental drug (other than glutamine or Omegaven) within 3 months or 5.5 half-lives of the experimental drug, whichever is longer, prior to screening, and for the duration of the study.
• •12. Previous use of teduglutide or native/synthetic glucagon-like peptide-2 (GLP-2)
• •13. Previous use of glucagon-like peptide-1 analog or human growth hormone within 3 months prior to screening
• •14. Previous use of octreotide, or dipeptidyl peptidase-4 (DPP-4) inhibitors within 3 months prior to screening
• •15. Subjects with active Crohn's disease who had been treated with biological therapy (eg, antitumor necrosis factor \[anti-TNF\]) within the 6 months prior to the screening visit
• •16. Subjects with inflammatory bowel disease (IBD) who require chronic systemic immunosuppressant therapy that had been introduced or changed during the 3 months prior to screening
• •17. More than 3 SBS-related or PN-related hospital admissions (eg, documented infection-related catheter sepsis, clots, bowel obstruction, severe water-electrolyte disturbances) within 3 months prior to the screening visit
• •18. Any major unscheduled hospital admission which affects parenteral support requirements within 1 month prior to or during screening, excluding uncomplicated treatment of bacteremia, central line replacement/repair, or issues of similar magnitude in an otherwise stable subject
• •19. Body weight \< 10 kg at the screening and baseline visits
• •20. Signs of active severe or unstable, clinically significant hepatic impairment during the screening period, as indicated by any of the following laboratory test results :
• •1. Total bilirubin (TBL) ≥ 2 x upper limit of normal (ULN)
• •2. Aspartate aminotransferase (AST) ≥ 7x ULN
• •3. Alanine aminotransferase (ALT) ≥ 7x ULN
• •For subjects with Gilbert's disease:
• •4. Indirect (unconjugated) bilirubin ≥ 2x ULN
• •21. Signs of known continuous active or unstable, clinically significant renal dysfunction shown by results of an estimated glomerular filtration rate (eGFR) below 50 mL/min/1.73 m2.
• •22. Parent(s) and/or subjects who are not capable of understanding or not willing to adhere to the study visit schedule and other protocol requirements
• •23. Unstable, clinically significant active, untreated pancreatic or biliary disease
• •24. Any condition, disease, illness, or circumstance that in the investigator's opinion puts the subject at any undue risk, prevents completion of the study, or interferes with analysis of the study results.