Effects of Liposomal Bupivacaine for Acute Pain in Hip and Femur Fractures

Exclusion Criteria

• •1. \>10 hours since presentation to the emergency department
• •2. History of seizure disorder, recent seizure or a document intra-cranial hemorrhage.
• •3. Central or peripheral neurologic deficit on presentation
• •4. Concern or compartment syndrome
• •5. Associated additional long bone fractures
• •6. End stage liver failure
• •7. Renal failure requiring dialysis
• •8. Pregnancy or breast feeding
• •9. Prisoners
• •10. Coagulopathy with INR \>1.5
• •11. Use of direct thrombin inhibitors (bivalirudin, argatroban, desirudin, dabigatran etexilate), or direct factor Xa inhibitors (rivaroxaban, apixaban, edoxaban)
• •12. Suspected prolonged intubation within first 12 hours secondary to respiratory failure other than peri-procedurally
• •13. Adults unable to consent
• •14. Pediatric patients \<18 years old
• •15. Patients exhibiting signs of shock upon admission, HR \>120 or SBP \<100 mmHg.
• •16. History of allergic reaction to local anesthetics
• •17. Administration of any other local anesthetic in the 2 hours prior to the study enrollment.
• •18. Distal femur fractures