Age

18–75

Sex

ALL

Healthy volunteers

Not accepted

Ages of 18 to 75, male or female;
Main renal artery, with or without accessary renal arteries, with length
* 20mm;
Patients who have not taken any anti-hypertensive drugs or have been off drugs for at least 2 weeks, with mean SBP ≥150mmHg and
* 180mmHg based on at least 3 office blood pressure measurements, or ASBP≥135mmHg and ≤170mmHg based on 24 hr blood pressure monitoring;
Agrees to take part in the trial and signs the written, informed consent.

Renal artery abnormalities that are inappropriate for the procedure;
Pregnant or plan to become pregnant;
History of orthostatic hypotension;
Type I diabetes;
Estimated GFR\<40mL/min/1.73m2;
Only one kidney or prior kidney transplantation;
Bleeding tendency or other coagulation related diseases;
Acute or severe systemic infection;
Prior renal artery interventional procedures or prior RDN treatment;
History of stroke or TIA;
Malignant tumor or end-stage illnesses;
Secondary hypertension;
Acute coronary events within 2 weeks;
Other conditions that deem unsuitable for the procedure, in the opinions of investigators.

Renal Denervation for the Treatment of Hypertension: A Pilot Safety and Efficacy Study